OBJECTIVE: In patients with septic shock, multiple organ failure (MOF) is associated with high levels of interleukin-6 (IL-6). Although organ failure is also a common complication of cardiogenic shock (CS), IL-6 levels have been reported to be lower in patients with CS than in patients with septic shock. We studied IL-6 plasma levels in patients with CS with respect to organ failure. SETTING: Eight-bed intensive care unit at a university hospital. PATIENTS: Fifty-one patients with CS, 26 patients with septic shock, and 11 noncritically ill controls. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patients with CS had higher IL-6 levels than noncritically ill controls ( p<.001) but lower levels than patients with septic shock ( p=.003). CS patients with MOF at the time of blood sampling exhibited, however, higher IL-6 levels than CS patients without organ failure, and IL-6 levels in patients with CS correlated to the total Sepsis-related Organ Failure Assessment score at the time of blood sampling ( r=.57, <.001). No significant differences in IL-6 levels were found when comparing CS patients with MOF at the time of blood sampling with patients with septic shock. Furthermore, CS patients who developed MOF during ICU stay exhibited significantly higher IL-6 levels than CS patients who never did develop MOF. An IL-6 level of >200 pg/mL had a 93% specificity and 100% sensitivity for the prediction of MOF in patients with CS. CONCLUSIONS: Once MOF is present, patients with CS exhibit similarly high IL-6 levels as patients with septic shock. High IL-6 levels in CS patients are associated with a progression to MOF.
OBJECTIVE: In patients with septic shock, multiple organ failure (MOF) is associated with high levels of interleukin-6 (IL-6). Although organ failure is also a common complication of cardiogenic shock (CS), IL-6 levels have been reported to be lower in patients with CS than in patients with septic shock. We studied IL-6 plasma levels in patients with CS with respect to organ failure. SETTING: Eight-bed intensive care unit at a university hospital. PATIENTS: Fifty-one patients with CS, 26 patients with septic shock, and 11 noncritically ill controls. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:Patients with CS had higher IL-6 levels than noncritically ill controls ( p<.001) but lower levels than patients with septic shock ( p=.003). CS patients with MOF at the time of blood sampling exhibited, however, higher IL-6 levels than CS patients without organ failure, and IL-6 levels in patients with CS correlated to the total Sepsis-related Organ Failure Assessment score at the time of blood sampling ( r=.57, <.001). No significant differences in IL-6 levels were found when comparing CS patients with MOF at the time of blood sampling with patients with septic shock. Furthermore, CS patients who developed MOF during ICU stay exhibited significantly higher IL-6 levels than CS patients who never did develop MOF. An IL-6 level of >200 pg/mL had a 93% specificity and 100% sensitivity for the prediction of MOF in patients with CS. CONCLUSIONS: Once MOF is present, patients with CS exhibit similarly high IL-6 levels as patients with septic shock. High IL-6 levels in CS patients are associated with a progression to MOF.
Authors: Spaska A Stanilova; Zhivko T Karakolev; Gospodin S Dimov; Zlatka G Dobreva; Lyuba D Miteva; Emil S Slavov; Chavdar S Stefanov; Noyko S Stanilov Journal: Intensive Care Med Date: 2005-02-18 Impact factor: 17.440
Authors: Adriano A M Truffa; Christopher B Granger; Kyle R White; L Kristin Newby; Rajendra H Mehta; Judith S Hochman; Manesh R Patel; Karen S Pieper; Hussein R Al-Khalidi; Paul W Armstrong; Renato D Lopes Journal: JACC Cardiovasc Interv Date: 2012-07 Impact factor: 11.195
Authors: Roland Prondzinsky; Susanne Unverzagt; Henning Lemm; Nikolas-Arne Wegener; Axel Schlitt; Konstantin M Heinroth; Sebastian Dietz; Ute Buerke; Patrick Kellner; Harald Loppnow; Martin G Fiedler; Joachim Thiery; Karl Werdan; Michael Buerke Journal: Clin Res Cardiol Date: 2012-01-03 Impact factor: 5.460
Authors: Massimo Antonelli; Mitchell Levy; Peter J D Andrews; Jean Chastre; Leonard D Hudson; Constantine Manthous; G Umberto Meduri; Rui P Moreno; Christian Putensen; Thomas Stewart; Antoni Torres Journal: Intensive Care Med Date: 2007-04 Impact factor: 17.440