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Literature DB >> 12351187

Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart.

J A Montero¹, B Giron, H Arrechedera, Y-C Cheng, P Scotting, J Chimal-Monroy, J A Garcia-Porrero, J M Hurle.

Abstract

We describe the expression pattern of Sox8, Sox9 and Sox10 during the development of the chick embryo heart. These Sox genes constitute the group E of the large Sox family of transcription factors. We show that the expression of Sox8, Sox9 and Sox10 in the developing heart correlates with heart septation and with the differentiation of the connective tissue of the valve leaflets. Sox10 appears also as a specific marker of developing heart nerves. These findings fit with the occurrence of morphological and functional anomalies of the heart reported in humans deficient for Sox9 and Sox10.

Entities: Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12351187 DOI： 10.1016/s0925-4773(02)00249-6

Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882

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Cited

22 in total

1. Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization.

Authors: Nils Klüver; Mariko Kondo; Amaury Herpin; Hiroshi Mitani; Manfred Schartl
Journal: Dev Genes Evol Date: 2005-04-08 Impact factor: 0.900

Review 2. Heart Valve Biomechanics and Underlying Mechanobiology.

Authors: Salma Ayoub; Giovanni Ferrari; Robert C Gorman; Joseph H Gorman; Frederick J Schoen; Michael S Sacks
Journal: Compr Physiol Date: 2016-09-15 Impact factor: 9.090

Review 3. Sox9 and programming of liver and pancreatic progenitors.

Authors: Yoshiya Kawaguchi
Journal: J Clin Invest Date: 2013-05-01 Impact factor: 14.808

4. Heart morphogenesis gene regulatory networks revealed by temporal expression analysis.

Authors: Jonathon T Hill; Bradley Demarest; Bushra Gorsi; Megan Smith; H Joseph Yost
Journal: Development Date: 2017-08-14 Impact factor: 6.868

5. VEGF signaling has distinct spatiotemporal roles during heart valve development.

Authors: Kryn Stankunas; Gene K Ma; Frank J Kuhnert; Calvin J Kuo; Ching-Pin Chang
Journal: Dev Biol Date: 2010-09-15 Impact factor: 3.582

6. A Case of Agonadism, Skeletal Malformations, Bicuspid Aortic Valve, and Delayed Development with a 16p13.3 Duplication Including GNG13 and SOX8 Upstream Enhancers: Are Either, Both or Neither Involved in the Phenotype?

Authors: R P Erickson; S A Yatsenko; K Larson; S W Cheung
Journal: Mol Syndromol Date: 2010-11-13

Expression of Sox8, Sox9 and Sox10 in the developing valves and autonomic nerves of the embryonic heart.

1. Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization.

Review 2. Heart Valve Biomechanics and Underlying Mechanobiology.

Review 3. Sox9 and programming of liver and pancreatic progenitors.

4. Heart morphogenesis gene regulatory networks revealed by temporal expression analysis.

5. VEGF signaling has distinct spatiotemporal roles during heart valve development.

6. A Case of Agonadism, Skeletal Malformations, Bicuspid Aortic Valve, and Delayed Development with a 16p13.3 Duplication Including GNG13 and SOX8 Upstream Enhancers: Are Either, Both or Neither Involved in the Phenotype?

7. SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals.

8. Sox9b is required for epicardium formation and plays a role in TCDD-induced heart malformation in zebrafish.

9. Fibulin-1 is required for morphogenesis of neural crest-derived structures.

Review 10. Aggrecan in Cardiovascular Development and Disease.