Literature DB >> 12350421

Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.

Frank Schuettauf1, Kristine Quinto, Rita Naskar, David Zurakowski.   

Abstract

We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.

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Year:  2002        PMID： 12350421     DOI： 10.1016/s0042-6989(02)00188-8

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  39 in total

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