| Literature DB >> 12350333 |
Marie-Josée Santoni1, Pierre Pontarotti, Daniel Birnbaum, Jean-Paul Borg.
Abstract
Recently, the LAP (for 'LRR and PDZ') family of adaptor proteins was described in vertebrates and invertebrates. The proteins are involved in cell polarity and receptor targeting, and they contain both LRR and PDZ domains in the same molecule, a combination that is specifically bilaterian. A search of available genome sequences reveals a limited number of lap genes, which we have classified by phylogenetic analysis. We propose a functional hypothesis for the origin of this protein family in bilaterians, and give a phylogenetic interpretation of their diversity.Mesh：
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Year: 2002 PMID： 12350333 DOI： 10.1016/s0168-9525(02)02738-5
Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639