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Literature DB >> 12350160

Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp.

Philip G Williams¹, Wesley Y Yoshida, Richard E Moore, Valerie J Paul.

Abstract

The acyclic peptide tasiamide (1) has been isolated from the marine cyanobacterium Symploca sp. The planar structure and absolute stereochemistry of the peptide were deduced by 2D NMR techniques and chiral HPLC. Tasiamide (1) was cytotoxic against KB and LoVo cells with IC(50) values of 0.48 and 3.47 microg/mL, respectively.

Entities: Chemical

Mesh：

Substances：
Oligopeptides
tasiamide

Year: 2002 PMID： 12350160 DOI： 10.1021/np020184q

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

12 in total

Review 1. Chemical genetic approaches to probing cell death.

Authors: Nidhi M Gangadhar; Brent R Stockwell
Journal: Curr Opin Chem Biol Date: 2006-12-14 Impact factor: 8.822

2. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.

Authors: Fatma H Al-Awadhi; Brian K Law; Valerie J Paul; Hendrik Luesch
Journal: J Nat Prod Date: 2017-10-31 Impact factor: 4.050

Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp.

Review 1. Chemical genetic approaches to probing cell death.

2. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.

Review 3. Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

4. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.

Review 5. Marine Peptides: Bioactivities and Applications.

6. Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

Review 7. Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential.

Review 8. Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis.

9. Lipopeptides from the tropical marine cyanobacterium Symploca sp.

Review 10. Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides.