Literature DB >> 1234490

Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

M J Hayes, M J Langman, A H Short.   

Abstract

1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.

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Year:  1975        PMID： 1234490      PMCID： PMC1402501          DOI： 10.1111/j.1365-2125.1975.tb00475.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  10 in total

1.  The metabolic fate of diphenylhydantoin in the dog, rat and man.

Authors:  E W MAYNERT
Journal:  J Pharmacol Exp Ther       Date:  1960-11       Impact factor: 4.030

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  A graphic method for the determination and presentation of binding parameters in a complex system.

Authors:  H E Rosenthal
Journal:  Anal Biochem       Date:  1967-09       Impact factor: 3.365

4.  Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.

Authors:  P K Lunde; A Rane; S J Yaffe; L Lund; F Sjöqvist
Journal:  Clin Pharmacol Ther       Date:  1970 Nov-Dec       Impact factor: 6.875

5.  Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.

Authors:  J MacGee
Journal:  Anal Chem       Date:  1970-03       Impact factor: 6.986

6.  Serum protein binding of thyroxine and diphenylhydantoin.

Authors:  R W Lightfoot; C L Christian
Journal:  J Clin Endocrinol Metab       Date:  1966-03       Impact factor: 5.958

7.  The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid.

Authors:  A T Ness; H C Dickerson; J V Pastewka
Journal:  Clin Chim Acta       Date:  1965-11       Impact factor: 3.786

8.  Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium.

Authors:  R A O'Reilly
Journal:  J Clin Invest       Date:  1967-05       Impact factor: 14.808

9.  Effect of age and sex on human drug metabolism.

Authors:  K O'Malley; J Crooks; E Duke; I H Stevenson
Journal:  Br Med J       Date:  1971-09-11

10.  The rate of decline of diphenylhydantoin in human plasma.

Authors:  K Arnold; N Gerber
Journal:  Clin Pharmacol Ther       Date:  1970 Jan-Feb       Impact factor: 6.903
  10 in total
  43 in total

1.  Pharmacokinetics in the aged: a review.

Authors:  E J Triggs; R L Nation
Journal:  J Pharmacokinet Biopharm       Date:  1975-12

2.  Editorial: drug metabolism and increasing age.

Authors: 
Journal:  Br Med J       Date:  1975-06-14

Review 3.  Hepatic drug metabolism and aging.

Authors:  C Durnas; C M Loi; B J Cusack
Journal:  Clin Pharmacokinet       Date:  1990-11       Impact factor: 6.447

4.  The 'apparent clearance' of free phenytoin in elderly vs. younger adults.

Authors:  Daniel F B Wright; Evan J Begg
Journal:  Br J Clin Pharmacol       Date:  2010-07       Impact factor: 4.335

5.  Drugs in the elderly.

Authors:  J R Trounce
Journal:  Br J Clin Pharmacol       Date:  1975-08       Impact factor: 4.335

6.  Age as a determinant of sensitivity to warfarin.

Authors:  A M Shepherd; D S Hewick; T A Moreland; I H Stevenson
Journal:  Br J Clin Pharmacol       Date:  1977-06       Impact factor: 4.335

Review 7.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

Review 8.  Drug prescribing in hepatobiliary disease.

Authors:  R K Roberts; P V Desmond; S Schenker
Journal:  Drugs       Date:  1979-03       Impact factor: 9.546

9.  Disposition of sodium valproate in epileptic patients.

Authors:  E Perucca; G Gatti; G M Frigo; A Crema; S Calzetti; D Visintini
Journal:  Br J Clin Pharmacol       Date:  1978-06       Impact factor: 4.335

Review 10.  Pharmacokinetics in the elderly.

Authors:  J Crooks; K O'Malley; I H Stevenson
Journal:  Clin Pharmacokinet       Date:  1976       Impact factor: 6.447
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