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Literature DB >> 1234489

Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins.

Abstract

1 A decrease was found in the binding capacity of elderly people for warfarin. 2 The decrease in binding correlated with a fall in plasma albumin concentrations. 3 No changes in the association constant were observed.

Entities: Chemical Species

Mesh：

Substances：
Serum Albumin
Warfarin

Year: 1975 PMID： 1234489 PMCID： PMC1402487 DOI： 10.1111/j.1365-2125.1975.tb00474.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

9 in total

1. The plasma protein pattern and its significance in geriatrics and cancer diagnosis.

Authors: I A PARFENTJEV; M L JOHNSON
Journal: Geriatrics Date: 1955-05

2. The significance of haemorrhage during the treatment of patients with the coumarin anticoagulants.

Authors: M A PEYMAN
Journal: Acta Med Scand Suppl Date: 1958

3. Electrophoretic studies on the serum of normal aged individuals.

Authors: H A RAFSKY; A A BRILL; K G STERN; H COREY
Journal: Am J Med Sci Date: 1952-11 Impact factor: 2.378

4. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

5. Serum protein in an aging population with particular reference to evaluation of immune globulins and antibodies.

Authors: O Haferkamp; D Schlettwein-Gsell; H G Schwick; K Störiko
Journal: Gerontologia Date: 1966

6. The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid.

Authors: A T Ness; H C Dickerson; J V Pastewka
Journal: Clin Chim Acta Date: 1965-11 Impact factor: 3.786

7. Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium.

Authors: R A O'Reilly
Journal: J Clin Invest Date: 1967-05 Impact factor: 14.808

8. Predisposing factors in adverse reactions to drugs.

Authors: N Hurwitz
Journal: Br Med J Date: 1969-03-01

9. Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin.

Authors: R A O'Reilly
Journal: J Clin Invest Date: 1969-01 Impact factor: 14.808

9 in total

24 in total

1. Pharmacokinetics in the aged: a review.

Authors: E J Triggs; R L Nation
Journal: J Pharmacokinet Biopharm Date: 1975-12

2. Editorial: drug metabolism and increasing age.

Authors:
Journal: Br Med J Date: 1975-06-14

3. Venous thromboembolism in patients with membranous nephropathy.

Authors: Sophia Lionaki; Vimal K Derebail; Susan L Hogan; Sean Barbour; Taewoo Lee; Michelle Hladunewich; Allen Greenwald; Yichun Hu; Caroline E Jennette; J Charles Jennette; Ronald J Falk; Daniel C Cattran; Patrick H Nachman; Heather N Reich
Journal: Clin J Am Soc Nephrol Date: 2011-11-10 Impact factor: 8.237

Review 10. Pharmacokinetics in the elderly.

Authors: J Crooks; K O'Malley; I H Stevenson
Journal: Clin Pharmacokinet Date: 1976 Impact factor: 6.447