Literature DB >> 1234484

A single dose study of trazodone with an assessment of its effect on mood and arousal.

B Munday, M J Kendall, M Mitchard.   

Abstract

1 A pharmacokinetic study of a single oral dose of a new antidepressant (trazodone) is described, linked to an attempt to measure changes in mood and arousal induced by the drug in normal subjects. 2 The drug had a measurable effect on arousal, but not on mood. It caused bradycardia (compared with placebo) and this persisted through the following night's sleep. This effect has not been completely explained. 3 The technique of mood and arousal measurement employed in this study seems potentially useful.

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Year:  1975        PMID： 1234484      PMCID： PMC1402486          DOI： 10.1111/j.1365-2125.1975.tb00466.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  3 in total

Review 1.  Measurement of feelings using visual analogue scales.

Authors:  R C Aitken
Journal:  Proc R Soc Med       Date:  1969-10

Review 2.  Clinical experience with a new psychotropic drug, trazodone: a review of literature.

Authors:  R U Udabe
Journal:  Curr Ther Res Clin Exp       Date:  1973-10

3.  A short clinical diagnostic self-rating scale for psychoneurotic patients. The Middlesex Hospital Questionnaire (M.H.Q.).

Authors:  S Crown; A H Crisp
Journal:  Br J Psychiatry       Date:  1966-09       Impact factor: 9.319
  3 in total
  6 in total

1.  The effect of thyrotropin releasing hormone on measures of mood in normal women.

Authors:  T A Betts; J Smith; S Pidd; J Mackintosh; P Harvey
Journal:  Br J Clin Pharmacol       Date:  1976-06       Impact factor: 4.335

2.  The electrocardiographic and anticholinergic effects of trazodone and imipramine in man.

Authors:  C D Burgess; T K Hames; C F George
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

3.  Trazodone--a new assay procedure and some pharmacokinetic parameters.

Authors:  S I Ankier; B K Martin; M S Rogers; P K Carpenter; C Graham
Journal:  Br J Clin Pharmacol       Date:  1981-05       Impact factor: 4.335

4.  The effects of four antihypertensive agents on the Stroop colour-word test in normal male volunteer subjects.

Authors:  P G Harvey; A B Clayton; T A Betts
Journal:  Psychopharmacology (Berl)       Date:  1977-10-20       Impact factor: 4.530

Review 5.  Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-06       Impact factor: 9.546

6.  Amphetamine, mazindol, and fencamfamin in narcolepsy.

Authors:  J Shindler; M Schachter; S Brincat; J D Parkes
Journal:  Br Med J (Clin Res Ed)       Date:  1985-04-20
  6 in total

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