| Literature DB >> 12341905 |
M Idaomar, J F Guerin, J Lornage, P Moncharmont, J C Czyba.
Abstract
An investigation was conducted to evaluate the motility and metabolism of human spermatozoa incubated at 37 degrees Celsius for 3 hours in a krebs phosphate Ringer solution containing different concentrations of 17beta-estradiol and tamoxifen. 17beta-estradiol (17beta E2) stimulated significantly the motility of human spermatozoa. The oxidative metabolism and the intracellular ATP concentrations are enhanced with 10-20 mcg/ml of 17beta E2; the lactate production remains unchanged however. Tamoxifen, an antiestrogen, inhibited the motility of spermatozoa, and was toxic at high concentrations. Its effects on the energetic metabolism is dose-dependent; it increases the oxidative metabolism and decreases the lactate production and intracellular ATP at 3 mcg/ml.Entities:
Keywords: Biology; Endocrine System; Estradiol--analysis; Estradiol--side effects; Estrogens; Evaluation; Examinations And Diagnoses; Family Planning; Fertility Agents; Genitalia; Germ Cells; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Physiology; Reproduction; Reproductive Control Agents; Sperm Transport; Spermatozoa--analysis; Tamoxifen--analysis; Tamoxifen--side effects; Urogenital System
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Year: 1987 PMID： 12341905
Source DB: PubMed Journal: Adv Contracept Deliv Syst ISSN： 1012-8689