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Literature DB >> 1233994

Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.

J D Robinson, B A Morris, G W Aherne, V Marks.

Abstract

1. Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose of phenytoin sodium (100 mg). 2. Two distinct peaks were found at 2.5-3.5 and 10-12 h after ingestion. Maximum serum concentrations ranged from 1.56 mug/ml. The mean plasma half-life of the drug under these conditions was 9.81 +/- 0.66 (s.e. mean) hours.

Entities: Chemical Species

Mesh：

Substances：
Phenytoin

Year: 1975 PMID： 1233994 PMCID： PMC1402591 DOI： 10.1111/j.1365-2125.1975.tb02782.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

1. Development of a radioimmunoassay for etorphine (preliminary communication).

Authors: J D Robinson; B A Morris; V Marks
Journal: Res Commun Chem Pathol Pharmacol Date: 1975-01

Review 2. Measurement of therapeutic agents in blood.

Authors: V Marks; W E Lindup; E M Baylis
Journal: Adv Clin Chem Date: 1973 Impact factor: 5.394

3. Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.

Authors: H Kutt; S Louis
Journal: Drugs Date: 1972 Impact factor: 9.546

4. Radioimmunoassay and saturation analysis. Pharmacology.

Authors: V Marks; B A Morris; J D Teale
Journal: Br Med Bull Date: 1974-01 Impact factor: 4.291

5. A radioimmunoassay for diphenylhydantoin.

Authors: R E Tigelaar; R L Rapport; J K Inman; H J Kupferberg
Journal: Clin Chim Acta Date: 1973-01-24 Impact factor: 3.786

6. A rapid micro-method for determining four anti-convulsant drugs by gas-liquid chromatography.

Authors: A S Papadopoulos; E M Baylis; D E Fry; V Marks
Journal: Clin Chim Acta Date: 1973-10-12 Impact factor: 3.786

7. Pharmacokinetics of single and multiple doses of phenytoin in man.

Authors: L Lund; G Alvan; A Berlin; B Alexanderson
Journal: Eur J Clin Pharmacol Date: 1974 Impact factor: 2.953

8. Antiserum to diphenylhydantoin: preparation and characterization.

Authors: C E Cook; J A Kepler; H D Christensen
Journal: Res Commun Chem Pathol Pharmacol Date: 1973-05

9. Metabolic disposition of diphenylhydantoin in normal human subjects following intravenous administration.

Authors: A J Glazko; T Chang; J Baukema; W A Dill; J R Goulet; R A Buchanan
Journal: Clin Pharmacol Ther Date: 1969 Jul-Aug Impact factor: 6.875

10. The rate of decline of diphenylhydantoin in human plasma.

Authors: K Arnold; N Gerber
Journal: Clin Pharmacol Ther Date: 1970 Jan-Feb Impact factor: 6.903

7 in total

1. Piperine in food: interference in the pharmacokinetics of phenytoin.

Authors: T Velpandian; R Jasuja; R K Bhardwaj; J Jaiswal; S K Gupta
Journal: Eur J Drug Metab Pharmacokinet Date: 2001 Oct-Dec Impact factor: 2.441

2. Application of a simplified method to determine bioavailability of an oral dose of phenytoin.

Authors: A L Davis; E J Begg; M C Kennedy; G G Graham
Journal: J Pharmacokinet Biopharm Date: 1993-04

3. Saliva carbamazepine and phenytoin level monitoring.

Authors: G W Rylance; T A Moreland
Journal: Arch Dis Child Date: 1981-08 Impact factor: 3.791

4. The effect of activated dimethicone and a proprietary antacid preparation containing this agent on the absorption of phenytoin.

Authors: J C McElnay; G Uprichard; P S Collier
Journal: Br J Clin Pharmacol Date: 1982-04 Impact factor: 4.335