Literature DB >> 1233264

Quantitation of phenobarbital and its main metabolites in human urine.

N Kallberg, S Agurell, O Ericsson, E Bucht, B Jalling, L O Boréus.   

Abstract

A method for the quantitative determination of phenobarbital and free and conjugated p-hydroxyphenobarbital in urine samples is described. The method includes initial extraction, purification on a small chromatographic column and finally determination by gas chromatography. The barbituric acids are methylated by trimethylanilinium hydroxide which serves as a "flash heater" methylating agent. The conjugate of p-hydroxyphenobarbital, which appears to be a glucuronide, is hydrolysed with hydrochloric acid.

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Year:  1975        PMID： 1233264     DOI： 10.1007/bf00614013

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  18 in total

1.  Epoxides as microsomal metabolites of polycyclic hydrocarbons.

Authors:  P L. Grover; A Hewer; P Sims
Journal:  FEBS Lett       Date:  1971-10-15       Impact factor: 4.124

2.  [A study of C-14 labelled phenobarbital in the body of the rat. 2].

Authors:  B GLASSON; A BENAKIS
Journal:  Helv Physiol Pharmacol Acta       Date:  1961

3.  The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin.

Authors:  T C BUTLER
Journal:  J Pharmacol Exp Ther       Date:  1957-01       Impact factor: 4.030

4.  Metabolite of phenobarbital in human urine.

Authors:  E J ALGERI; A J MCBAY
Journal:  Science       Date:  1956-02-03       Impact factor: 47.728

5.  Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene.

Authors:  F Oesch; N Morris; J W Daly
Journal:  Mol Pharmacol       Date:  1973-09       Impact factor: 4.436

6.  Detection of a 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-metabolite of phenobarbital and mephobarbital in rat, guinea pig and human.

Authors:  D J Harvey; L Glazener; C Stratton; J Nowlin; R M Hill; M G Horning
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1972-05

7.  Metabolic profiles: gas-phase methods for analysis of metabolites.

Authors:  E C Horning; M G Horning
Journal:  Clin Chem       Date:  1971-08       Impact factor: 8.327

8.  Identification of 5-meta-hydroxyphenyl-5-phenylhydantoin as a metabolite of diphenylhydantoin.

Authors:  A J Atkinson; J MacGee; J Strong; D Garteiz; T E Gaffney
Journal:  Biochem Pharmacol       Date:  1970-08       Impact factor: 5.858

9.  Gas chromatography of barbiturates, phenolic alkaloids, and xanthine bases: flash-heater methylation by means of trimethylanilinium hydroxide.

Authors:  E Brochmann-Hanssen; T O Oke
Journal:  J Pharm Sci       Date:  1969-03       Impact factor: 3.534

10.  Quantitative assay of 5,5-diphenylhydantoin (Dilantin) and 5-(p-hydroxyphenyl)-5-phenylhydantoin by gas-liquid chromatography.

Authors:  T Chang; A J Glazko
Journal:  J Lab Clin Med       Date:  1970-01
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  3 in total

1.  Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.

Authors:  P A Winstanley; C R Newton; G Pasvol; F J Kirkham; E Mberu; N Peshu; S A Ward; J B Were; D A Warrell; K Marsh
Journal:  Br J Clin Pharmacol       Date:  1992-02       Impact factor: 4.335

Review 2.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

3.  The fate of phenobarbitone in children in hypothermia and at normal body temperature.

Authors:  D Kadar; B K Tang; A W Conn
Journal:  Can Anaesth Soc J       Date:  1982-01
  3 in total

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