Literature DB >> 1233210

General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments.

D P Vaughan, D J Mallard, A Trainor, M Mitchard.   

Abstract

General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readily obtainable using disposition and input functions.

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Year:  1975        PMID： 1233210     DOI： 10.1007/bf00561564

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  11 in total

1.  ON SOME TOPOLOGICAL PROPERTIES OF THE SYSTEMS OF COMPARTMENTS.

Authors:  A RESCIGNO
Journal:  Bull Math Biophys       Date:  1964-03

2.  Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man.

Authors:  A H Beckett; J A Salmon
Journal:  J Pharm Pharmacol       Date:  1972-02       Impact factor: 3.765

3.  Comparative pharmacokinetics of coumarin anticoagulants. IV. Application of a three-compartmental model to the analysis of the dose-dependent kinetics of bishydroxycoumarin elimination.

Authors:  R Nagashima; G Levy; R A O'Reilly
Journal:  J Pharm Sci       Date:  1968-11       Impact factor: 3.534

4.  Pharmacokinetics of trichloroethanol and metabolites and interconversions among variously referenced pharmacokinetic parameters.

Authors:  E R Garrett; H J Lambert
Journal:  J Pharm Sci       Date:  1973-04       Impact factor: 3.534

5.  General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.

Authors:  L Z Benet
Journal:  J Pharm Sci       Date:  1972-04       Impact factor: 3.534

6.  Pharmacokinetic basis for the influence of route of administration on the area under the plasma concentration-time curve.

Authors:  M Gibaldi; S Feldman
Journal:  J Pharm Sci       Date:  1969-12       Impact factor: 3.534

7.  Some pharmacokinetic aspects of 5-(dimethylriazeno)-imidazole-4-carboxamide in the dog.

Authors:  T L Loo; B B Tanner; G E Housholder; B J Shepard
Journal:  J Pharm Sci       Date:  1968-12       Impact factor: 3.534

8.  Multicompartment pharmacokinetic models and pharmacologic effects.

Authors:  G Levy; M Gibaldi; W J Jusko
Journal:  J Pharm Sci       Date:  1969-04       Impact factor: 3.534

9.  An analysis of the inter-subject variation in the metabolism of pentazocine.

Authors:  D P Vaughan; A H Beckett
Journal:  J Pharm Pharmacol       Date:  1974-10       Impact factor: 3.765

10.  On some metric properties of the systems of compartments.

Authors:  A Rescigno; G Segre
Journal:  Bull Math Biophys       Date:  1965-09
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  3 in total

1.  General derivation of the ideal intravenous drug input required to achieve and maintain a constant plasma drug concentration. Theoretical application to lignocaine therapy.

Authors:  D P Vaughan; G T Tucker
Journal:  Eur J Clin Pharmacol       Date:  1976       Impact factor: 2.953

2.  Development of a complex parent-metabolite joint population pharmacokinetic model.

Authors:  Julie Bertrand; Céline M Laffont; France Mentré; Marylore Chenel; Emmanuelle Comets
Journal:  AAPS J       Date:  2011-05-27       Impact factor: 4.009

3.  Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat.

Authors:  B E Dahlström; L K Paalzow
Journal:  J Pharmacokinet Biopharm       Date:  1978-12
  3 in total

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