E Hogervorst1, D J Lehmann, D R Warden, J McBroom, A D Smith. 1. Oxford Project To Investigate Memory and Ageing, Department of Pharmacology, Radcliffe, Infirmary, Oxford, UK. eva.hogervorst@pharm.ox.ac.uk
Abstract
OBJECTIVES: To assess the association between testosterone levels and APOEepsilon4 in cases with AD and controls. METHOD: We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer). RESULTS: We found that both low serum testosterone and the interaction between testosterone and APOEepsilon4 were associated with AD. Furthermore, testosterone levels were lower in APOEepsilon4-positive controls (mean: 11.3 nmol/L) than in controls without the allele (19.1 nmol/L). CONCLUSIONS: Low testosterone is potentially a modifiable risk factor, which may prove relevant to APOEepsilon4 carriers who are at risk of AD. Copyright 2002 John Wiley & Sons, Ltd.
OBJECTIVES: To assess the association between testosterone levels and APOEepsilon4 in cases with AD and controls. METHOD: We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer). RESULTS: We found that both low serum testosterone and the interaction between testosterone and APOEepsilon4 were associated with AD. Furthermore, testosterone levels were lower in APOEepsilon4-positive controls (mean: 11.3 nmol/L) than in controls without the allele (19.1 nmol/L). CONCLUSIONS: Low testosterone is potentially a modifiable risk factor, which may prove relevant to APOEepsilon4 carriers who are at risk of AD. Copyright 2002 John Wiley & Sons, Ltd.
Authors: Matthew S Panizzon; Richard L Hauger; Lindon J Eaves; Chi-Hua Chen; Anders M Dale; Lisa T Eyler; Bruce Fischl; Christine Fennema-Notestine; Carol E Franz; Michael D Grant; Kristen C Jacobson; Amy J Jak; Michael J Lyons; Sally P Mendoza; Michael C Neale; Elizabeth Prom-Wormley; Larry J Seidman; Ming T Tsuang; Hong Xian; William S Kremen Journal: Neuroimage Date: 2011-10-01 Impact factor: 6.556
Authors: M S Panizzon; R Hauger; A M Dale; L J Eaves; L T Eyler; B Fischl; C Fennema-Notestine; C E Franz; M D Grant; A J Jak; K C Jacobson; M J Lyons; S P Mendoza; M C Neale; E C Prom-Wormley; L J Seidman; M T Tsuang; H Xian; W S Kremen Journal: Neurology Date: 2010-09-07 Impact factor: 9.910