Literature DB >> 12324251

Two-component and phosphorelay signal-transduction systems as therapeutic targets.

Keith Stephenson1, James A Hoch.   

Abstract

Two-component and phosphorelay signal-transduction systems of pathogenic bacteria control the expression of genes encoding virulence factors and essential functions. Recent systematic gene inactivation studies have confirmed the integral role of two-component systems in the pathogenesis of diseases caused by several microorganisms and highlighted the validity of using these systems as targets for therapeutic intervention. Structural studies of signal-transduction proteins have recently revealed common features that may allow rational drug design for therapeutic intervention. In particular, the conserved domains of response regulators may represent the best targets for inhibition.

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Year:  2002        PMID： 12324251     DOI： 10.1016/s1471-4892(02)00194-7

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  49 in total

1.  The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

Authors:  Nikhilesh S Chand; Jenny See-Wai Lee; Anne E Clatworthy; Aaron J Golas; Roger S Smith; Deborah T Hung
Journal:  J Bacteriol       Date:  2011-04-22       Impact factor: 3.490

2.  Lactoferricin B inhibits the phosphorylation of the two-component system response regulators BasR and CreB.

Authors:  Yu-Hsuan Ho; Tzu-Cheng Sung; Chien-Sheng Chen
Journal:  Mol Cell Proteomics       Date:  2011-12-02       Impact factor: 5.911

3.  Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype.

Authors:  Henrik Tomenius; Anna-Karin Pernestig; Claudia F Méndez-Catalá; Dimitris Georgellis; Staffan Normark; Ojar Melefors
Journal:  J Bacteriol       Date:  2005-11       Impact factor: 3.490

4.  New class of competitive inhibitor of bacterial histidine kinases.

Authors:  Raymond Gilmour; J Estelle Foster; Qin Sheng; Jonathan R McClain; Anna Riley; Pei-Ming Sun; Wai-Leung Ng; Dalai Yan; Thalia I Nicas; Kenneth Henry; Malcolm E Winkler
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

5.  Teaching old drugs new tricks: Addressing resistance in Francisella.

Authors:  Erik A Feldmann; John Cavanagh
Journal:  Virulence       Date:  2015       Impact factor: 5.882

Review 6.  Roles of two-component regulatory systems in antibiotic resistance.

Authors:  Aimee Rp Tierney; Philip N Rather
Journal:  Future Microbiol       Date:  2019-05-08       Impact factor: 3.165

7.  SaeRS Is Responsive to Cellular Respiratory Status and Regulates Fermentative Biofilm Formation in Staphylococcus aureus.

Authors:  Ameya A Mashruwala; Casey M Gries; Tyler D Scherr; Tammy Kielian; Jeffrey M Boyd
Journal:  Infect Immun       Date:  2017-07-19       Impact factor: 3.441

8.  Inhibition of Salmonella enterica biofilm formation using small-molecule adenosine mimetics.

Authors:  Jacob A Koopman; Joanna M Marshall; Aditi Bhatiya; Tadesse Eguale; Jesse J Kwiek; John S Gunn
Journal:  Antimicrob Agents Chemother       Date:  2014-10-13       Impact factor: 5.191

9.  VirR-Mediated Resistance of Listeria monocytogenes against Food Antimicrobials and Cross-Protection Induced by Exposure to Organic Acid Salts.

Authors:  Jihun Kang; Martin Wiedmann; Kathryn J Boor; Teresa M Bergholz
Journal:  Appl Environ Microbiol       Date:  2015-04-24       Impact factor: 4.792

10.  Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production.

Authors:  Sarah Underwood; Shuang Guan; Vinod Vijayasubhash; Simon D Baines; Luke Graham; Richard J Lewis; Mark H Wilcox; Keith Stephenson
Journal:  J Bacteriol       Date:  2009-09-25       Impact factor: 3.490
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