| Literature DB >> 12324250 |
David J C Knowles1, Nicolas Foloppe, Natalia B Matassova, Alastair I H Murchie.
Abstract
Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes.Entities:
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Year: 2002 PMID： 12324250 DOI： 10.1016/s1471-4892(02)00205-9
Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547