Literature DB >> 12323394

Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.

Anthony J Williams1, Jitendra R Dave, X May Lu, Geoff Ling, Frank C Tortella.   

Abstract

Staurosporine-induced apoptosis was associated with a 20% cellular survival rate in primary rat forebrain cultures. Treatment with the NR2B subunit-selective NMDA receptor antagonist conantokin-G (0.1-1 microM) increased the survival rate up to 78%. No protection was provided by the nonselective NMDA receptor antagonist dizocilpine (0.01-10 microM) but 34-64% cellular survival was provided by ifenprodil (0.01-10 microM), another NR2B subunit-selective antagonist. These results suggest a novel anti-apoptotic mechanism linked to the NR2B receptor subunit. Copyright 2002 Elsevier Science B.V.

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Year:  2002        PMID： 12323394     DOI： 10.1016/s0014-2999(02)02327-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo.

Authors:  Li Guo; Thomas E Salt; Annelie Maass; Vy Luong; Stephen E Moss; Fred W Fitzke; M Francesca Cordeiro
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-02       Impact factor: 4.799

2.  A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory.

Authors:  Janice W Smith; Francois Gastambide; Gary Gilmour; Sophie Dix; Julie Foss; Kirstie Lloyd; Nadia Malik; Mark Tricklebank
Journal:  Psychopharmacology (Berl)       Date:  2011-04-12       Impact factor: 4.530

3.  Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors.

Authors:  Z Sheng; M Prorok; F J Castellino
Journal:  Neuroscience       Date:  2010-08-03       Impact factor: 3.590

4.  Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation.

Authors:  Luoxiu Huang; Rashna D Balsara; Zhenyu Sheng; Francis J Castellino
Journal:  Mol Cell Neurosci       Date:  2010-06-21       Impact factor: 4.314

5.  CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.

Authors:  Anitha B Alex; Gerald W Saunders; Alexandre Dalpé-Charron; Christopher A Reilly; Karen S Wilcox
Journal:  Neurotoxicology       Date:  2011-03-17       Impact factor: 4.294

6.  Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists.

Authors:  Jitendra R Dave; Anthony J Williams; John R Moffett; Michael L Koenig; Frank C Tortella
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.911

7.  The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

Authors:  Zhenyu Sheng; Zhong Liang; James H Geiger; Mary Prorok; Francis J Castellino
Journal:  Neuropharmacology       Date:  2009-05-08       Impact factor: 5.250

8.  Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats.

Authors:  A J Williams; G Ling; R Berti; J R Moffett; C Yao; X M Lu; J R Dave; F C Tortella
Journal:  Exp Brain Res       Date:  2003-08-29       Impact factor: 1.972

Review 9.  Assessment of neuroprotection in the retina with DARC.

Authors:  Li Guo; M Francesca Cordeiro
Journal:  Prog Brain Res       Date:  2008       Impact factor: 2.453

10.  Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats.

Authors:  Papia Mondal; Surendra Kumar Trigun
Journal:  Evid Based Complement Alternat Med       Date:  2015-08-27       Impact factor: 2.629
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