| Literature DB >> 12323024 |
Tadashi Eguchi1, Kayako Kobayashi, Hidehiro Uekusa, Yuji Ohashi, Kazutoshi Mizoue, Yoshitaka Matsushima, Katsumi Kakinuma.
Abstract
The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray diffraction of degradative derivatives. The absolute configuration of FD-891 turned out to be as shown above. The stable conformer of FD-891 was also discussed with respect to biological activity by comparison with the structurally related concanamycin A on the bases of molecular mechanics calculations. [structure: see text]Entities:
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Year: 2002 PMID： 12323024 DOI： 10.1021/ol026518k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005