| Literature DB >> 12323023 |
David A Evans1, Jimmy Wu, Craig E Masse, David W C MacMillan.
Abstract
An efficient enantioselective synthesis of beta,beta-dialkyl-gamma-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)](Cl)(2)(+), R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in high enantiomeric excesses. [reaction: see text]Entities:
Year: 2002 PMID： 12323023 DOI： 10.1021/ol026489d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005