| Literature DB >> 12322709 |
Kenneth M Rassnick1, Glenna E Mauldin, Renee Al-Sarraf, G Neal Mauldin, Antony S Moore, Samantha C Mooney.
Abstract
The purpose of this retrospective study was to evaluate the efficacy and toxicity of the MOPP chemotherapy protocol (mechlorethamine, vincristine, procarbazine, and prednisone) as a rescue regimen in dogs with lymphoma. One hundred seventeen dogs that had resistance to previously administered chemotherapy were evaluated. Before treatment with MOPP, all dogs received a median of 6 chemotherapy drugs for a median duration of 213 days. Thirty-one percent (36 of 117) had a complete response (CR) to MOPP for a median of 63 days, and 34% (40 of 117) had a partial response (PR) for a median of 47 days. Sixteen percent (19 of 117) had stable disease (SD) for a median of 33 days. Predictors for response to MOPP were not identified. Gastrointestinal (GI) toxicity occurred in 28% (33 of 117) of the dogs, and 13% (15 dogs) required hospitalization. Five dogs developed septicemia, and 2 died as a result. MOPP was an effective treatment for dogs with resistant lymphoma and was well tolerated by the majority of affected dogs.Entities:
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Year: 2002 PMID： 12322709 DOI： 10.1892/0891-6640(2002)016<0576:mcftor>2.3.co;2
Source DB: PubMed Journal: J Vet Intern Med ISSN： 0891-6640 Impact factor: 3.333