[Toxicity of ochratoxin A. II.--Effects of treatment on the progeny (F1 and F2) of intoxicated rats (author's transl)].

A group of pregnant rats is given a total of 5 mg/kg of ochratoxin A orally for two (lot A) and four (lot B) days. Treatment begins at day 8 post coitum for both lots. The progeny of these females are recorded and studied (F1 and F2). A description of litter size and ponderal growth of F1 individuals shows the results of the effects of the treatment of the mothers on this generation: reduced litters and late growth. Moreover, there is a high proportion of hydrocephalus which affects only the males. Finally, no effect was observed on F2 animals.