Literature DB >> 1230131

Cerebrospinal fluid levels of chlorpromazine and it metabolites in schizophrenia.

S Axelsson, S Jönsson, L Nordgren.   

Abstract

The concentrations of chlorpromazine and some of its metabolites in blood plasma and CSF from chlorpromazine-treated schizophrenics with different therapeutic results were studied. Compared to a good responder a poor responder showed very high levels of the inactive metabolite chlorpromazine sulphoxide in the CSF.

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Year:  1975        PMID： 1230131     DOI： 10.1007/bf00431052

Source DB:  PubMed          Journal:  Arch Psychiatr Nervenkr (1970)


  9 in total

1.  Thin-layer chromatography of chlorpromazine metabolites. Attempt to identify each of the metabolites appearing in blood, urine and feces of chronically medicated schizophrenics.

Authors:  P Turano; W J Turner; A A Manian
Journal:  J Chromatogr       Date:  1973-01-17

2.  Physiologic and clinical effects of chlorpromazine and their relationship to plasma level.

Authors:  G Sakalis; S H Curry; G P Mould; M H Lader
Journal:  Clin Pharmacol Ther       Date:  1972 Nov-Dec       Impact factor: 6.875

3.  Effect of chlorpromazine and some of its metabolites on synthesis and turnover of catecholamines formed from 14 C-tyrosine in mouse brain.

Authors:  H Nybäck; G Sedvall
Journal:  Psychopharmacologia       Date:  1972

4.  A method for determination of chlorpromazine in human blood serum.

Authors:  G W Christoph; D E Schmidt; J M Davis; D S Janowsky
Journal:  Clin Chim Acta       Date:  1972-05       Impact factor: 3.786

5.  Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma using gas-liquid chromatography with an electron capture detector.

Authors:  S H Curry
Journal:  Anal Chem       Date:  1968-07       Impact factor: 6.986

6.  Chlorpromazine metabolite pattern in psychotic patients.

Authors:  M B Wechsler; R N Wharton; E Tanaka; S Malitz
Journal:  J Psychiatr Res       Date:  1967-12       Impact factor: 4.791

7.  Appearance of monohydroxylated chlorpromazine metabolites in the central nervous system.

Authors:  A A Manian; D H Efron; S R Harris
Journal:  Life Sci I       Date:  1971-06-15

8.  A comparative pharmacological study of a series of monohydroxylated and methoxylated chlorpromazine derivatives.

Authors:  A A Manian; D H Efron; M E Goldberg
Journal:  Life Sci       Date:  1965-12       Impact factor: 5.037

9.  The relationship of plasma chlorpromazine to its 7-hydroxy and sulphoxide metabolites in a large population of chronic schizophrenics.

Authors:  A V Mackay; A F Healey; J Baker
Journal:  Br J Clin Pharmacol       Date:  1974-10       Impact factor: 4.335
  9 in total
  1 in total

1.  Predictive indices for chlorpromazine therapy in schizophrenics.

Authors:  P A Dixon; E Oforah; R Makanjuola
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335
  1 in total

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