Literature DB >> 12297588

Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy.

Eduardo E Benarroch1, Ann M Schmeichel, Joseph E Parisi.   

Abstract

The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 +/- 2 vs 81 +/- 10 cells/section, p< 0.001) and laterodorsal tegmental nucleus (18 +/- 3 vs 47 +/- 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.

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Year:  2002        PMID: 12297588     DOI: 10.1212/wnl.59.6.944

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  22 in total

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Review 5.  Brainstem in multiple system atrophy: clinicopathological correlations.

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Review 6.  Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases.

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8.  Loss of A5 noradrenergic neurons in multiple system atrophy.

Authors:  Eduardo E Benarroch; Ann M Schmeichel; Phillip A Low; Paola Sandroni; Joseph E Parisi
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9.  Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure.

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Journal:  Arch Neurol       Date:  2009-06

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