| Literature DB >> 12297277 |
Yun-Jung Lee1, Jung-Hyun Park, Sung-Kyu Ju, Kwan-Hee You, Jea Seung Ko, Hyun-Man Kim.
Abstract
The genetic defect in producing the adipose hormone leptin results among others in a drastic increase of bone mass. The current understanding is that under normal circumstances, osteoblast activity is indirectly suppressed by a hypothalamic relay induced by leptin-signalling in the brain. To investigate whether leptin might also regulate osteoblast activity in a direct manner, expression of leptin receptors in rat osteoblasts was determined and their functionality was analyzed upon recombinant leptin treatment. Reverse transcription-PCR confirmed the expression of four among the six currently described receptor isoforms, which were also able to transduce cell signalling as shown by STAT3 phosphorylation after activation.Entities:
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Year: 2002 PMID： 12297277 DOI： 10.1016/s0014-5793(02)02889-2
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124