| Literature DB >> 12297112 |
Hyun-Hee Shin1, Byoung S Kwon, Hye-Seon Choi.
Abstract
Stimulation of murine macrophages with recombinant soluble glucocorticoid induced tumour necrosis factor receptor (GITR) induced cyclooxygenase (COX)-2 protein and generated significant amounts of PGE(2). Previous result demonstrated that macrophages express GITR and GITR ligand constitutively. Induction of COX-2 was synergistic with interferon (INF)-gamma. GITR/ligand system could deliver an activation signal to macrophages in inflammatory processes. Copyright 2002 Elsevier Science Ltd.Entities:
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Year: 2002 PMID: 12297112 DOI: 10.1006/cyto.2002.1962
Source DB: PubMed Journal: Cytokine ISSN: 1043-4666 Impact factor: 3.861