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Literature DB >> 12296721

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.

Ho-Sang Moon¹, Eric M Jacobson, Sonya M Khersonsky, Michael R Luzung, Daniel P Walsh, Wennan Xiong, Jae Wook Lee, Puja B Parikh, Jennifer C Lam, Tae-Wook Kang, Gustavo R Rosania, Alexander F Schier, Young-Tae Chang.

Abstract

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

Entities: Chemical Species

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Year: 2002 PMID： 12296721 DOI： 10.1021/ja026720i

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

19 in total

Review 1. A cheminformatic toolkit for mining biomedical knowledge.

Authors: Gus R Rosania; Gordon Crippen; Peter Woolf; David States; Kerby Shedden
Journal: Pharm Res Date: 2007-03-24 Impact factor: 4.200

2. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

Authors: Sujin Lee; Puay-Wah Phuan; Christian M Felix; Joseph-Anthony Tan; Marc H Levin; Alan S Verkman
Journal: J Med Chem Date: 2017-01-31 Impact factor: 7.446

3. A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

Authors: Lynn C Usher; Andrea Johnstone; Ali Ertürk; Ying Hu; Dinara Strikis; Ina B Wanner; Sanne Moorman; Jae-Wook Lee; Jaeki Min; Hyung-Ho Ha; Yuanli Duan; Stanley Hoffman; Jeffrey L Goldberg; Frank Bradke; Young-Tae Chang; Vance P Lemmon; John L Bixby
Journal: J Neurosci Date: 2010-03-31 Impact factor: 6.167

4. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.

Authors: Heather P Harding; Yuhong Zhang; Sonya Khersonsky; Stefan Marciniak; Donalyn Scheuner; Randal J Kaufman; Norman Javitt; Young-Tae Chang; David Ron
Journal: Cell Metab Date: 2005-12 Impact factor: 27.287

5. 1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization.

Authors: Lubna Ghani; Chastine F Munk; Xiang Zhang; Satoshi Katsube; Yang Du; Cristina Cecchetti; Weijiao Huang; Hyoung Eun Bae; Savvas Saouros; Muhammad Ehsan; Lan Guan; Xiangyu Liu; Claus J Loland; Brian K Kobilka; Bernadette Byrne; Pil Seok Chae
Journal: J Am Chem Soc Date: 2019-12-06 Impact factor: 15.419

6. Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of Lyngbya isolated from the Florida Everglades.

Authors: John P Berry; Miroslav Gantar; Robert E Gawley; Minglei Wang; Kathleen S Rein
Journal: Comp Biochem Physiol C Toxicol Pharmacol Date: 2004-12 Impact factor: 3.228

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.

Review 1. A cheminformatic toolkit for mining biomedical knowledge.

2. Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases.

3. A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

4. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression.

5. 1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization.

6. Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of Lyngbya isolated from the Florida Everglades.

7. Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.

Review 8. Advances in zebrafish chemical screening technologies.

9. Dendrimers terminated with dichlorotriazine groups provide a route to compositional diversity.

Review 10. Use of non-mammalian alternative models for neurotoxicological study.