OBJECT: The purpose of this study was to establish a standard curve to demonstrate normal age-related changes in the proportion of intracranial cerebrospinal fluid (CSF) space in intracranial volume (ICV) during each decade of life. METHODS: Using volumetric computerized tomography (CT) scanning and computer-guided volume measurement software, ICV and cerebral parenchymal volume (CPV) for each decade of life were measured and the intracranial CSF ratio was calculated by the following formula: percentage of CSF = (ICV - CPV)/ICV x 100%. The standard curve for age-related changes in normal percentages of intracranial CSF was obtained. CONCLUSIONS: Based on this standard curve, the percentage of intracranial CSF rapidly increased after the sixth decade, seeming to reflect the brain atrophy that accompanies increased age.
OBJECT: The purpose of this study was to establish a standard curve to demonstrate normal age-related changes in the proportion of intracranial cerebrospinal fluid (CSF) space in intracranial volume (ICV) during each decade of life. METHODS: Using volumetric computerized tomography (CT) scanning and computer-guided volume measurement software, ICV and cerebral parenchymal volume (CPV) for each decade of life were measured and the intracranial CSF ratio was calculated by the following formula: percentage of CSF = (ICV - CPV)/ICV x 100%. The standard curve for age-related changes in normal percentages of intracranial CSF was obtained. CONCLUSIONS: Based on this standard curve, the percentage of intracranial CSF rapidly increased after the sixth decade, seeming to reflect the brain atrophy that accompanies increased age.
Authors: János A Perge; Shaomin Zhang; Wasim Q Malik; Mark L Homer; Sydney Cash; Gerhard Friehs; Emad N Eskandar; John P Donoghue; Leigh R Hochberg Journal: J Neural Eng Date: 2014-06-12 Impact factor: 5.379
Authors: Akinobu Watanabe; Paul M Gignac; Amy M Balanoff; Todd L Green; Nathan J Kley; Mark A Norell Journal: J Anat Date: 2018-12-03 Impact factor: 2.610