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Literature DB >> 1227510

Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells.

A Cryer, A McDonald, E R Williams, D S Robinson.

Abstract

When isolated fat-cells are incubated at 25 degrees C in serum-based media containing glucose, insulin and heparin, the rise that occurs in the clearing-factor lipase activity of the incubation medium is inhibited by colchicine. The rise in the fat-cell clearing-factor lipase activity that occurs during similar incubations in the absence of heparin is not affected by colchicine.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1975 PMID： 1227510 PMCID： PMC1172531 DOI： 10.1042/bj1520717

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

24 in total

1. Inhibition by colchicine of carbamylcholine induced glycoprotein secretion by the submaxillary gland. A possible mechanism of cholinergic induced protein secretion.

Authors: B Rossignol; G Herman; G Keryer
Journal: FEBS Lett Date: 1972-03-15 Impact factor: 4.124

2. Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices.

Authors: F R Butcher; R H Goldman
Journal: Biochem Biophys Res Commun Date: 1972-07-11 Impact factor: 3.575

3. Inhibition by colchicine and by vinblastine of acetylcholine-induced catecholamine release from the adrenal gland: an anticholinergic action, not an effect upon microtubules.

Authors: J M Trifaró; B Collier; A Lastowecka; D Stern
Journal: Mol Pharmacol Date: 1972-03 Impact factor: 4.436

4. Hormonal control of adipose tissue clearing factor lipase activity.

Authors: P Davies; A Cryer; D S Robinson
Journal: FEBS Lett Date: 1974-09-01 Impact factor: 4.124

5. Evidence for a role of the microtubular system in the secretion of newly synthesized albumin and other proteins by the liver.

Authors: Y Le Marchand; C Patzelt; F Assimacopoulos-Jeannet; E G Loten; B Jeanrenaud
Journal: J Clin Invest Date: 1974-06 Impact factor: 14.808

1. The lipoprotein lipase of white adipose tissue. Changes in the adipocyte cell-surface content of enzyme in response to extracellular effectors in vitro.

Authors: A A Al-Jafari; A Cryer
Journal: Biochem J Date: 1986-08-15 Impact factor: 3.857

1 in total

Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells.

1. Inhibition by colchicine of carbamylcholine induced glycoprotein secretion by the submaxillary gland. A possible mechanism of cholinergic induced protein secretion.

2. Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices.

3. Inhibition by colchicine and by vinblastine of acetylcholine-induced catecholamine release from the adrenal gland: an anticholinergic action, not an effect upon microtubules.

4. Hormonal control of adipose tissue clearing factor lipase activity.

5. Evidence for a role of the microtubular system in the secretion of newly synthesized albumin and other proteins by the liver.

6. Release of lipoprotein lipase activity from isolated fat cells. II. Effect of heparin.

7. New hypothesis of insulin secretion.

8. The clearing-factor lipase activity of isolated fat-cells.

9. Effects of cytochalasin B, colchicine and vincristine on the metabolism of isolated fat-cells.

10. Inhibition of free fatty acid mobilization by colchicine.

1. The lipoprotein lipase of white adipose tissue. Changes in the adipocyte cell-surface content of enzyme in response to extracellular effectors in vitro.