BACKGROUND: Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions. AIMS: To report preliminary data on self-perceived and objectively measurable neurocognition in prodromal patients of the first German early recognition centre. METHOD: Subjective neuropsychological disturbances were assessed in 51 patients with potentially prodromal symptoms of schizophrenia. Initial neurocognitive functioning was compared with matched normals and patients with schizophrenia. RESULTS: Self-perceived deficits mostly concerned perception, cognition and stress reactivity. Five transitions happened during the 15-month follow-up. Recently emerging or intensifying deficits were to some extent predictive of transition. Persons at risk performed worse than controls on objectively measured verbal capacity, attention and memory functions. CONCLUSIONS: Neuropsychological deficits, either self-perceived or objectively measured, characterise persons at risk for schizophrenia and may contribute to predicting transitions.
BACKGROUND: Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions. AIMS: To report preliminary data on self-perceived and objectively measurable neurocognition in prodromal patients of the first German early recognition centre. METHOD: Subjective neuropsychological disturbances were assessed in 51 patients with potentially prodromal symptoms of schizophrenia. Initial neurocognitive functioning was compared with matched normals and patients with schizophrenia. RESULTS: Self-perceived deficits mostly concerned perception, cognition and stress reactivity. Five transitions happened during the 15-month follow-up. Recently emerging or intensifying deficits were to some extent predictive of transition. Persons at risk performed worse than controls on objectively measured verbal capacity, attention and memory functions. CONCLUSIONS: Neuropsychological deficits, either self-perceived or objectively measured, characterise persons at risk for schizophrenia and may contribute to predicting transitions.
Authors: Larry J Seidman; Anthony J Giuliano; Eric C Meyer; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Elaine F Walker; Scott W Woods; Carrie E Bearden; Bruce K Christensen; Keith Hawkins; Robert Heaton; Richard S E Keefe; Robert Heinssen; Barbara A Cornblatt Journal: Arch Gen Psychiatry Date: 2010-06
Authors: Ingo Frommann; Ralf Pukrop; Jürgen Brinkmeyer; Andreas Bechdolf; Stephan Ruhrmann; Julia Berning; Petra Decker; Michael Riedel; Hans-Jürgen Möller; Wolfgang Wölwer; Wolfgang Gaebel; Joachim Klosterkötter; Wolfgang Maier; Michael Wagner Journal: Schizophr Bull Date: 2010-01-06 Impact factor: 9.306