OBJECTIVES: The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress. METHODS: Two hundred twenty-two adolescents (mean age = 18.5 +/- 2.8 years; 130 [70 males] EAs and 92 [48 males] AAs) completed two stressors (video game, forehead cold). Hemodynamic measures and blood samples were collected at catheter insertion and before and immediately after the two stressors, separated by 20-minute rest periods. RESULTS: AAs and males exhibited higher levels of SBP and DBP and of TPRI and ET-1 at each sampling point compared with EAs and females, respectively (p values <.001). AAs and males exhibited greater increases in SBP, TPRI, and ET-1 in response to each stressor (p values <.05). Intraindividual correlations between ET-1 and hemodynamic parameters revealed that most individuals exhibited a positive association between ET-1, BP, and TPRI. However, some individuals exhibited a negative association between ET-1 and the above-mentioned hemodynamics, suggesting a compensatory vasodilation mechanism. CONCLUSION: The findings demonstrate significant sex and ethnicity differences in stress-induced vasoconstrictive peptide release and support the hypothesis that these differences may be important in explaining the ethnicity and sex differences in the prevalence of cardiovascular disease.
OBJECTIVES: The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress. METHODS: Two hundred twenty-two adolescents (mean age = 18.5 +/- 2.8 years; 130 [70 males] EAs and 92 [48 males] AAs) completed two stressors (video game, forehead cold). Hemodynamic measures and blood samples were collected at catheter insertion and before and immediately after the two stressors, separated by 20-minute rest periods. RESULTS: AAs and males exhibited higher levels of SBP and DBP and of TPRI and ET-1 at each sampling point compared with EAs and females, respectively (p values <.001). AAs and males exhibited greater increases in SBP, TPRI, and ET-1 in response to each stressor (p values <.05). Intraindividual correlations between ET-1 and hemodynamic parameters revealed that most individuals exhibited a positive association between ET-1, BP, and TPRI. However, some individuals exhibited a negative association between ET-1 and the above-mentioned hemodynamics, suggesting a compensatory vasodilation mechanism. CONCLUSION: The findings demonstrate significant sex and ethnicity differences in stress-induced vasoconstrictive peptide release and support the hypothesis that these differences may be important in explaining the ethnicity and sex differences in the prevalence of cardiovascular disease.
Authors: Mathew J Gregoski; Sarah G Buxbaum; Gaston Kapuku; Yanbin Dong; Haidong Zhu; Mary Davis; Kelsey Gonto; Frank A Treiber Journal: Ann Behav Med Date: 2013-06
Authors: Nicole B Gabler; Benjamin French; Brian L Strom; Ziyue Liu; Harold I Palevsky; Darren B Taichman; Steven M Kawut; Scott D Halpern Journal: Chest Date: 2011-09-22 Impact factor: 9.410
Authors: Antonio B Fernandez; Robert Soufer; Dorothea Collins; Aaron Soufer; Hooman Ranjbaran; Matthew M Burg Journal: Psychosom Med Date: 2010-04-05 Impact factor: 4.312
Authors: Haley N Jenkins; London J Williams; Adam Dungey; Kenneth D Vick; Bernadette E Grayson; Joshua S Speed Journal: Surg Obes Relat Dis Date: 2019-04-09 Impact factor: 4.734
Authors: Shaoyong Su; Xiaoling Wang; Gaston K Kapuku; Frank A Treiber; David M Pollock; Gregory A Harshfield; W Vaughn McCall; Jennifer S Pollock Journal: Hypertension Date: 2014-04-28 Impact factor: 10.190
Authors: Denise C Cooper; Paul J Mills; Wayne A Bardwell; Michael G Ziegler; Joel E Dimsdale Journal: Am J Hypertens Date: 2009-04-23 Impact factor: 2.689