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Literature DB >> 12270841

Novel locus required for expression of high-level macrolide-lincosamide-streptogramin B resistance in Staphylococcus aureus.

P K Martin¹, Y Bao, E Boyer, K M Winterberg, L McDowell, M B Schmid, J M Buysse.

Abstract

The yycF1(Ts) mutation in Staphylococcus aureus conferred hypersensitivity to macrolide-lincosamide-streptogramin B (MLS(B)) antibiotics on strains either containing or lacking ermB. The overexpression of the S. aureus Ssa protein restored the yycF1 mutant to wild-type levels of susceptibility. Inactivation of ssa in an unmutagenized strain dramatically reduced ermB-based resistance. Conditional loss of function or expression of ssa in the yycF1 mutant is proposed to result in the observed hypersensitivity to MLS(B) antibiotics.

Entities: Chemical Disease Species

Mesh：

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Year: 2002 PMID： 12270841 PMCID： PMC139611 DOI： 10.1128/JB.184.20.5810-5813.2002

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

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