Literature DB >> 12270510

Tumor necrosis factor-alpha inhibits physiologically identified dorsal motor nucleus neurons in vivo.

Gregory S Emch1, Gerlinda E Hermann, Richard C Rogers.   

Abstract

Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric distention. A large majority of physiologically identified DMN neurons are rapidly and completely inhibited by exposure to TNF-alpha, suggesting that TNF-alpha may induce gastric stasis by functioning as a hormone that modulates both portions of this reflex pathway during illness.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12270510     DOI： 10.1016/s0006-8993(02)03178-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Gastric vagal motoneuron function is maintained following experimental spinal cord injury.

Authors:  E M Swartz; G M Holmes
Journal:  Neurogastroenterol Motil       Date:  2014-10-15       Impact factor: 3.598

2.  Cholecystokinin octapeptide increases spontaneous glutamatergic synaptic transmission to neurons of the nucleus tractus solitarius centralis.

Authors:  V Baptista; Z L Zheng; F H Coleman; R C Rogers; R A Travagli
Journal:  J Neurophysiol       Date:  2005-08-10       Impact factor: 2.714

3.  Alpha-1 adrenergic input to solitary nucleus neurones: calcium oscillations, excitation and gastric reflex control.

Authors:  Gerlinda E Hermann; Jason S Nasse; Richard C Rogers
Journal:  J Physiol       Date:  2004-11-11       Impact factor: 5.182

4.  TNFα causes thrombin-dependent vagal neuron apoptosis in inflammatory bowel disease.

Authors:  Danielle Fritze; Weizhen Zhang; Ji-Yao Li; Biaoxin Chai; Michael W Mulholland
Journal:  J Gastrointest Surg       Date:  2014-06-25       Impact factor: 3.452

5.  Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output.

Authors:  K Zhao; Y Ao; R M Harper; V L W Go; H Yang
Journal:  Neuroscience       Date:  2013-05-20       Impact factor: 3.590

Review 6.  TNFalpha: a trigger of autonomic dysfunction.

Authors:  Gerlinda E Hermann; Richard C Rogers
Journal:  Neuroscientist       Date:  2007-10-02       Impact factor: 7.519

7.  TNF activates astrocytes and catecholaminergic neurons in the solitary nucleus: implications for autonomic control.

Authors:  Gerlinda E Hermann; Richard C Rogers
Journal:  Brain Res       Date:  2009-04-05       Impact factor: 3.252

8.  Morphological differences between planes of section do not influence the electrophysiological properties of identified rat dorsal motor nucleus of the vagus neurons.

Authors:  Isabel Martinez-Peña y Valenzuela; Kirsteen N Browning; R Alberto Travagli
Journal:  Brain Res       Date:  2004-04-02       Impact factor: 3.252

Review 9.  Mechanisms of Cardiotoxicity of Cancer Chemotherapeutic Agents: Cardiomyopathy and Beyond.

Authors:  Rohit Moudgil; Edward T H Yeh
Journal:  Can J Cardiol       Date:  2016-02-02       Impact factor: 5.223

10.  CXCL12 sensitizes vago-vagal reflex neurons in the dorsal medulla.

Authors:  Richard C Rogers; Edouard Viard; Gerlinda E Hermann
Journal:  Brain Res       Date:  2012-11-23       Impact factor: 3.252
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.