| Literature DB >> 12270193 |
Christopher L Lynch1, Jeffrey J Hale, Richard J Budhu, Amy L Gentry, Sander G Mills, Kevin T Chapman, Malcolm MacCoss, Lorraine Malkowitz, Martin S Springer, Sandra L Gould, Julie A DeMartino, Salvatore J Siciliano, Margaret A Cascieri, Anthony Carella, Gwen Carver, Karen Holmes, William A Schleif, Renee Danzeisen, Daria Hazuda, Joseph Kessler, Janet Lineberger, Michael Miller, Emilio A Emini.
Abstract
A series of alpha-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over pyrrolidine 1.Entities:
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Year: 2002 PMID： 12270193 DOI： 10.1016/s0960-894x(02)00606-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823