| Literature DB >> 12270175 |
Michael L Curtin1, Robert B Garland, H Robin Heyman, Robin R Frey, Michael R Michaelides, Junling Li, Lori J Pease, Keith B Glaser, Patrick A Marcotte, Steven K Davidsen.
Abstract
A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.Entities:
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Year: 2002 PMID： 12270175 DOI： 10.1016/s0960-894x(02)00622-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823