| Literature DB >> 12270167 |
Roger A Smith1, Jinshan Chen, Mary M Mader, Ingo Muegge, Ulrike Moehler, Suresh Katti, Diana Marrero, William G Stirtan, Daniel R Weaver, Hong Xiao, William Carley.
Abstract
A library of benzofurans was prepared by solid-phase synthesis methods, and several analogues were identified as potent ligands for the estrogen receptors ER-alpha and ER-beta, with some compounds having selectivity for ER-alpha. Analogues designed to more closely mimic Raloxifene were less effective. Certain benzofurans were effective in a bone pit assay, but were characterized as agonists in a MCF-7 breast tumor cell proliferation assay.Entities:
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Year: 2002 PMID： 12270167 DOI： 10.1016/s0960-894x(02)00613-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823