| Literature DB >> 12270151 |
Nobutoshi Murakami1, Ying Ye, Motoyuki Kawanishi, Shunji Aoki, Nobuaki Kudo, Minoru Yoshida, Emi E Nakayama, Tatsuo Shioda, Motomasa Kobayashi.
Abstract
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.Entities:
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Year: 2002 PMID： 12270151 DOI： 10.1016/s0960-894x(02)00624-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823