Literature DB >> 12267

An investigation into the deposition of inhalation aerosol particles as a function of air flow rate in a modified 'Kirk Lung'.

P J Davies, G W Hanlon, A J Molyneux.   

Abstract

The effect of air flow rate on the deposition of inhalation aerosol particles in a modified 'Kirk Lung' has been studied. Two commercial products were used. The amount depositied in the mouthpiece and throat regions decreases with increasing flow rate. The amount in the collector rises to maximum of approximately 50%. This material represents the therapeutically available portion. Such an apparatus would be useful for routine quality control of the size distribution ratios for inhalation aerosol particles.

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Year:  1976        PMID： 12267     DOI： 10.1111/j.2042-7158.1976.tb04089.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  3 in total

1.  Pharmaceutical dry powder aerosols: correlation of powder properties with dose delivery and implications for pharmacodynamic effect.

Authors:  N M Concessio; M M VanOort; M R Knowles; A J Hickey
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

2.  Improved inhalation behavior of steroid KSR-592 in vitro with Jethaler by polymorphic transformation to needle-like crystals (beta-form).

Authors:  Kazuhiko Ikegami; Yoshiaki Kawashima; Hirofumi Takeuchi; Hiromitsu Yamamoto; Nobuyuki Isshiki; Den-Ichi Momose; Kiyohisa Ouchi
Journal:  Pharm Res       Date:  2002-10       Impact factor: 4.200

3.  Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method.

Authors:  Masayuki Watanabe; Tetsuya Ozeki; Tomoko Shibata; Hayato Murakoshi; Yuuki Takashima; Hiroshi Yuasa; Hiroaki Okada
Journal:  AAPS PharmSciTech       Date:  2003-12-16       Impact factor: 3.246
  3 in total

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