Renal blood flow and function during neuroleptanaesthesia and at elevated intravesical pressure. An experimental study in the pig.

During two hours of neuroleptanaesthesia in five pigs, renal blood flow was unchanged, whereas renal vascular resistance and the mean arterial blood pressure increased. The glomerular function was not significantly altered. The tubular function was moderately impaired. The intravesical pressure was successively elevated in seven pigs. This caused no changes in renal blood flow. The renal vascular resistance increased parallelled by a slight increase of the mean arterial blood pressure. Both glomerular and tubular function decreased when the intravesical pressure was elevated to 50 mm Hg or above.