Literature DB >> 1225722

Induction of esophageal cancer associated with gastric cancer in a dog by N-ethyl-N'-nitro-N-nitrosoguandine.

H Sekizuka, H Doi, M Sunagawa, S Nagai, S Kojima.   

Abstract

The experimental induction of gastric cancer was studied in four dogs given oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in solution. Esophageal cancer with the regional lymph node metastasis was found in one dog at autopsy, with concomitantly existing gastric cancer. This dog, which ingested a total amount of about 38 g of ENNG, died of weakness on the 513th experimental day. Three remaining dogs are still living and under observation.

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Year:  1975        PMID: 1225722

Source DB:  PubMed          Journal:  Gan        ISSN: 0016-450X


  2 in total

1.  Esophageal carcinoma in house musk shrews, Suncus murinus (Insectivora), induced by N-methyl-N'-nitro-N-nitrosoguanidine.

Authors:  A Tsubura; H Senzaki; H Takahashi; T Oyaizu; S Morii
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

2.  Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine.

Authors:  M Kurihara; H Shirakabe; T Izumi; K Miyasaka; F Yamaya; T Maruyama; A Yasui
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-12-15
  2 in total

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