Literature DB >> 1225610

The importance of the conformation of the tetrahedral intermediate for the alpha-chymotrypsin-catalyzed hydrolysis of peptide substrates.

S A Bizzozero, B O Zweifel.   

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Year:  1975        PMID： 1225610     DOI： 10.1016/0014-5793(75)80351-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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  6 in total

Review 1.  Current problems in mechanistic studies of serine and cysteine proteinases.

Authors:  L Polgár; P Halász
Journal:  Biochem J       Date:  1982-10-01       Impact factor: 3.857

2.  Refined crystal structure of the molecular complex of Streptomyces griseus protease B, a serine protease, with the third domain of the ovomucoid inhibitor from turkey.

Authors:  M Fujinaga; R J Read; A Sielecki; W Ardelt; M Laskowski; M N James
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

3.  Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the papain catalytic mechanism.

Authors:  K Brocklehurst; J P Malthouse
Journal:  Biochem J       Date:  1978-11-01       Impact factor: 3.857

4.  Evidence that binding to the s2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25-histidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a hydrophobic side chain.

Authors:  K Brocklehurst; J P Malthouse; M Shipton
Journal:  Biochem J       Date:  1979-11-01       Impact factor: 3.857

5.  Evidence that the lack of high catalytic activity of thiolsubtilisin towards specific substrates may be due to an inappropriately located proton-distribution system. Demonstration of highly nucleophilic character of the thiol group of thiolsubtilisin in the catalytically relevant ionization state of the active centre by use of a two-protonic-state reactivity probe.

Authors:  K Brocklehurst; J P Malthouse
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857

6.  Stereoelectronic control in peptide bond formation. Ab initio calculations and speculations on the mechanism of action of serine proteases.

Authors:  D G Gorenstein; K Taira
Journal:  Biophys J       Date:  1984-12       Impact factor: 4.033
  6 in total

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