[Change in phosphatase and acid cathepsin activity in the dog cerebral cortex in terminal states].

Acid phosphatase, alkaline phosphatase and acid cathepsin activity increased in the subcellular fraction of the grey matter of dog brain in proportion to the duration of compression ischemia, particularly in the postmitochondrial supernatant. An increase in the alkaline phosphatase and of the acid cathepsin activity in the postmitochondrial supernatant was also observed at the period of clinical death caused by blood loss and preceded by hypotension of different duration and various levels of arterial pressure. Comparison of the above data indicated a common mechanism of proteolysis activation in the nervous tissue in the terminal states under study.