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Literature DB >> 12242256

Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac.

Mark Lunzer¹, Arvind Natarajan, Daniel E Dykhuizen, Antony M Dean.

Abstract

Trade-offs in catalytic efficiency at the lac permease of Escherichia coli produce alleles with different substrate specializations that are selectively favored on different galactosides. We show that differential resource utilization during competition for mixtures of galactosides produces frequency-dependent selection at lac. However, the polymorphism is protected only in a narrow range of galactoside ratios despite intense selection on the pure galactosides. Hence, stabilizing frequency-dependent selection protecting natural allozyme polymorphisms through differential resource utilization will be sporadic and ephemeral in randomly changing environments. A comparison of predictions, based on first principles, with experimental outcomes reveals an additional, unanticipated source of weak selection.

Entities: Chemical Species

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Year: 2002 PMID： 12242256 PMCID： PMC1462262

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

38 in total

Review 1. Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes.

Authors: W B Watt; A M Dean
Journal: Annu Rev Genet Date: 2000 Impact factor: 16.830

Review 2. The nature of selection on the major histocompatibility complex.

Authors: V Apanius; D Penn; P R Slev; L R Ruff; W K Potts
Journal: Crit Rev Immunol Date: 1997 Impact factor: 2.214

3. The degree of polymorphisms in enzymes involved in energy production compared to that in nonspecific enzymes in two Drosophila ananassae populations.

Authors: J H Gillespie; K Kojima
Journal: Proc Natl Acad Sci U S A Date: 1968-10 Impact factor: 11.205

Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac.

Review 1. Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes.

Review 2. The nature of selection on the major histocompatibility complex.

3. The degree of polymorphisms in enzymes involved in energy production compared to that in nonspecific enzymes in two Drosophila ananassae populations.

4. Confidence interval for the number of selectively neutral amino acid polymorphisms.

5. Relative roles of mutation and selection in the maintenance of genetic variability.

6. Periodic selection, infectious gene exchange and the genetic structure of E. coli populations.

7. OmpF changes and the complexity of Escherichia coli adaptation to prolonged lactose limitation.

8. Low synonymous site variation at the lacY locus in Escherichia coli suggests the action of positive selection.

9. A molecular investigation of genotype by environment interactions.

10. Ion channels are likely to be involved in the two steps of phage T5 DNA penetration into Escherichia coli cells.

1. Fitness consequences of a regulatory polymorphism in a seasonal environment.

2. Protecting haploid polymorphisms in temporally variable environments.

3. Measuring selection coefficients below 10(-3): method, questions, and prospects.

Review 4. Thoughts Toward a Theory of Natural Selection: The Importance of Microbial Experimental Evolution.

5. Selection in a cyclical environment: possible impact of phenotypic lag on Darwinian fitness.

6. Bounded population sizes, fluctuating selection and the tempo and mode of coexistence.

7. SIZE DOESN'T MATTER: MICROBIAL SELECTION EXPERIMENTS ADDRESS ECOLOGICAL PHENOMENA.

Review 8. Cancer in light of experimental evolution.

9. How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism.

10. Protozoan predation, diversifying selection, and the evolution of antigenic diversity in Salmonella.