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Literature DB >> 12242146

Blocking oncogenes in malignant cells by RNA interference--new hope for a highly specific cancer treatment?

Abstract

A little more than one year after the first demonstration that silencing of endogenous human genes is possible in cell culture, the new tool of RNA interference (RNAi) enters the field of tumor therapy.

Entities: Disease Species

Mesh：

Year: 2002 PMID： 12242146 DOI： 10.1016/s1535-6108(02)00129-0

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

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Cited

13 in total

1. A novel approach for evaluating the efficiency of siRNAs on protein levels in cultured cells.

Authors: Weilin Wu; Emily Hodges; Jenny Redelius; Christer Höög
Journal: Nucleic Acids Res Date: 2004-01-22 Impact factor: 16.971

2. Translational research: current status, challenges and future strategies.

Authors: Dale Yu
Journal: Am J Transl Res Date: 2011-09-12 Impact factor: 4.060

3. Silencing MAP3K1 expression through RNA interference enhances paclitaxel-induced cell cycle arrest in human breast cancer cells.

Authors: Pinghua Hu; Qin Huang; Zhihua Li; Xiaobo Wu; Qianwen Ouyang; Jun Chen; Yali Cao
Journal: Mol Biol Rep Date: 2013-11-21 Impact factor: 2.316

4. MUC1 plays a role in tumor maintenance in aggressive thyroid carcinomas.

Authors: Kepal N Patel; Ellie Maghami; Volkert B Wreesmann; Ashok R Shaha; Jatin P Shah; Ronald Ghossein; Bhuvanesh Singh
Journal: Surgery Date: 2005-12 Impact factor: 3.982

5. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.

Authors: Joyce A Wilson; Sumedha Jayasena; Anastasia Khvorova; Sarah Sabatinos; Ian Gaël Rodrigue-Gervais; Sudha Arya; Farida Sarangi; Marees Harris-Brandts; Sylvie Beaulieu; Christopher D Richardson
Journal: Proc Natl Acad Sci U S A Date: 2003-02-19 Impact factor: 11.205

Blocking oncogenes in malignant cells by RNA interference--new hope for a highly specific cancer treatment?

1. A novel approach for evaluating the efficiency of siRNAs on protein levels in cultured cells.

2. Translational research: current status, challenges and future strategies.

3. Silencing MAP3K1 expression through RNA interference enhances paclitaxel-induced cell cycle arrest in human breast cancer cells.

4. MUC1 plays a role in tumor maintenance in aggressive thyroid carcinomas.

5. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.

6. Herpes simplex virus thymidine kinase and ganciclovir suicide gene therapy for human pancreatic cancer.

7. siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells.

8. Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.

9. Novel insights into RNAi off-target effects using C. elegans paralogs.

10. The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12.