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Literature DB >> 12242108

The complexity of chromatin remodeling and its links to cancer.

Abstract

The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented.

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 12242108 DOI： 10.1016/s0304-419x(02)00067-7

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

34 in total

1. The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

Authors: Yutong Xue; Richard Gibbons; Zhijiang Yan; Dafeng Yang; Tarra L McDowell; Salvatore Sechi; Jun Qin; Sharleen Zhou; Doug Higgs; Weidong Wang
Journal: Proc Natl Acad Sci U S A Date: 2003-09-02 Impact factor: 11.205

2. Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses.

Authors: Joshua M Gilmore; Mihaela E Sardiu; Swaminathan Venkatesh; Brent Stutzman; Allison Peak; Chris W Seidel; Jerry L Workman; Laurence Florens; Michael P Washburn
Journal: Mol Cell Proteomics Date: 2011-12-22 Impact factor: 5.911

The complexity of chromatin remodeling and its links to cancer.

1. The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

2. Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses.

Review 3. Nuclear receptors and chromatin remodeling machinery.

4. Activation domains drive nucleosome eviction by SWI/SNF.

5. The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex.

6. Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.

7. Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene.

8. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription.

9. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis.

10. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.