Literature DB >> 12241099

Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection.

B Ranheim1, H Ween, A K Egeli, V Hormazabal, M Yndestad, N E Søli.   

Abstract

The disposition of penicillin G in piglets is described after intramuscular or subcutaneous injection of depot preparations. The piglets were injected with 33,000 IU/kg or 100,000 IU/kg benzathine + procaine penicillin G intramuscularly or subcutaneously, or 100,000 IU/kg procaine penicillin G intramuscularly or subcutaneously. Intramuscular injection of benzathine + procaine penicillin resulted in higher maximum concentrations in plasma (Cmax) than did subcutaneous injection. The mean residence time (MRT) of penicillin G was longer when the drugs were injected subcutaneously rather than intramuscularly. The plasma concentration versus time profiles of the subcutaneous injections of benzathine + procaine penicillin revealed secondary peaks, possibly reflecting a certain degree of inflammation at the injection site.

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Year:  2002        PMID： 12241099     DOI： 10.1023/a:1020590408947

Source DB:  PubMed          Journal:  Vet Res Commun        ISSN： 0165-7380            Impact factor:   2.459


  9 in total

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Authors:  G O Korsrud; J O Boison; M G Papich; W D Yates; J D MacNeil; E D Janzen; R D Cohen; D A Landry; G Lambert; M S Yong
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  9 in total
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  5 in total

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