Literature DB >> 12241038

How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis.

J H S Hofmeyr1, J M Rohwer, J L Snoep, H V Westerhoff, W N Konings.   

Abstract

A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This comparative model also serves as an example of numerical simulation with the scripting language Python and its scientific add-on Scipy.

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Year:  2002        PMID: 12241038     DOI: 10.1023/a:1020344922249

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN: 0301-4851            Impact factor:   2.316


  4 in total

1.  Modelling cellular processes with Python and Scipy.

Authors:  B G Olivier; J M Rohwer; J H S Hofmeyr
Journal:  Mol Biol Rep       Date:  2002       Impact factor: 2.316

2.  Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

Authors:  H Bolhuis; H W van Veen; D Molenaar; B Poolman; A J Driessen; W N Konings
Journal:  EMBO J       Date:  1996-08-15       Impact factor: 11.598

3.  Proton motive force-driven and ATP-dependent drug extrusion systems in multidrug-resistant Lactococcus lactis.

Authors:  H Bolhuis; D Molenaar; G Poelarends; H W van Veen; B Poolman; A J Driessen; W N Konings
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490

4.  Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

Authors:  H W van Veen; K Venema; H Bolhuis; I Oussenko; J Kok; B Poolman; A J Driessen; W N Konings
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

  4 in total
  2 in total

1.  The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters.

Authors:  Eliane H Yardeni; Smriti Mishra; Richard A Stein; Eitan Bibi; Hassane S Mchaourab
Journal:  J Mol Biol       Date:  2020-08-26       Impact factor: 5.469

Review 2.  Efflux-mediated drug resistance in bacteria.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2004       Impact factor: 9.546

  2 in total

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