Literature DB >> 12239297

Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1.

W M Cohen1, A Bianco, F Connan, L Camoin, M Dalod, G Lauvau, E Ferriès, B Culmann-Penciolelli, P M van Endert, J P Briand, J Choppin, J G Guillet.   

Abstract

Cytotoxic T-lymphocyte (CTL) responses directed to different human immunodeficiency virus (HIV) epitopes vary in their protective efficacy. In particular, HIV-infected cells are much more sensitive to lysis by anti-Gag/p17(77-85)/HLA-A2 than to that by anti-polymerase/RT(476-484)/HLA-A2 CTL, because of a higher density of p17(77-85) complexes. This report describes multiple processing steps favoring the generation of p17(77-85) complexes: (i) the exact COOH-terminal cleavage of epitopes by cellular proteases occurred faster and more frequently for p17(77-85) than for RT(476-484), and (ii) the binding efficiency of the transporter associated with antigen processing was greater for p17(77-85) precursors than for the RT(476-484) epitope. Surprisingly, these peptides, which differed markedly in their antigenicity, displayed qualitatively and quantitatively similar immunogenicity, suggesting differences in the mechanisms governing these phenomena. Here, we discuss the mechanisms responsible for such differences.

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Year:  2002        PMID： 12239297      PMCID： PMC136577          DOI： 10.1128/jvi.76.20.10219-10225.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  38 in total

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Review 5.  Mechanisms of MHC class I--restricted antigen processing.

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Authors:  G Lauvau; K Kakimi; G Niedermann; M Ostankovitch; P Yotnda; H Firat; F V Chisari; P M van Endert
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5.  Portable flanking sequences modulate CTL epitope processing.

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6.  Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons.

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  9 in total

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