Chie-Pein Chen1, Rekha Bajoria, John D Aplin. 1. Division of High Risk Pregnancy, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. cpchen@ms2.mmh.org.tw
Abstract
OBJECTIVE: The purpose of this study was to compare the morphologic features of placentas in severe intrauterine fetal growth restriction with abnormal umbilical artery blood flow velocity waveforms and normal gestation. STUDY DESIGN: Immunohistochemical methods were used to evaluate cell proliferation, vascular density, and alpha-smooth muscle actin expression by stromal cells in a group of 9 age-matched intrauterine growth-restricted and control placentas at 25 to 41 weeks of gestation. RESULTS: Fewer MIB1-positive nuclei were observed in both trophoblast and stromal cell populations in intrauterine growth restriction, which indicates fewer cells in cycle. Furthermore, a greatly reduced vascular density was observed, along with higher levels of alpha-smooth muscle actin expression in stromal cells. CONCLUSION: Intrauterine growth-restricted placentas show reduced cell proliferation in both trophoblast and stromal cell compartments. Peripheral villous vascularization is highly reduced.
OBJECTIVE: The purpose of this study was to compare the morphologic features of placentas in severe intrauterine fetal growth restriction with abnormal umbilical artery blood flow velocity waveforms and normal gestation. STUDY DESIGN: Immunohistochemical methods were used to evaluate cell proliferation, vascular density, and alpha-smooth muscle actin expression by stromal cells in a group of 9 age-matched intrauterine growth-restricted and control placentas at 25 to 41 weeks of gestation. RESULTS: Fewer MIB1-positive nuclei were observed in both trophoblast and stromal cell populations in intrauterine growth restriction, which indicates fewer cells in cycle. Furthermore, a greatly reduced vascular density was observed, along with higher levels of alpha-smooth muscle actin expression in stromal cells. CONCLUSION: Intrauterine growth-restricted placentas show reduced cell proliferation in both trophoblast and stromal cell compartments. Peripheral villous vascularization is highly reduced.
Authors: Suveena Ranzil; Stacey Ellery; David W Walker; Cathy Vaillancourt; Nadia Alfaidy; Alexander Bonnin; Anthony Borg; Euan M Wallace; Peter R Ebeling; Jan Jaap Erwich; Padma Murthi Journal: Placenta Date: 2019-05-23 Impact factor: 3.481
Authors: Jessica E Davies; Jürgen Pollheimer; Hannah E J Yong; Maria I Kokkinos; Bill Kalionis; Martin Knöfler; Padma Murthi Journal: Cell Adh Migr Date: 2016-04-12 Impact factor: 3.405