Literature DB >> 12237567

Accumulation of insoluble protein and aging.

Anund Hallén1.   

Abstract

It is proposed that biological aging mainly depends on a deleterious accumulation of insoluble inert protein that has escaped physiological proteolytic degradation. Intracellularly, a three-dimensional network of polypeptide chains may exclude macromolecular structures and organelles from part of the cytosolic water. In this way vital intracellular transport mechanisms may be obstructed, providing a rationale to several observations linked to aging.

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Year:  2002        PMID： 12237567     DOI： 10.1023/a:1020155502734

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  7 in total

1.  Hormetic modulation of aging and longevity by mild heat stress.

Authors:  Suresh I S Rattan
Journal:  Dose Response       Date:  2006-05-22       Impact factor: 2.658

2.  A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.

Authors:  Manuela Malatesta; Federica Boraldi; Giulia Annovi; Beatrice Baldelli; Serafina Battistelli; Marco Biggiogera; Daniela Quaglino
Journal:  Histochem Cell Biol       Date:  2008-07-22       Impact factor: 4.304

3.  Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells.

Authors:  Suresh I S Rattan; Yvonne E G Eskildsen-Helmond; Rasmus Beedholm
Journal:  Nonlinearity Biol Toxicol Med       Date:  2004-04

4.  Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage.

Authors:  Andrew M Pickering; Marcus Lehr; William J Kohler; Melissa L Han; Richard A Miller
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-07-28       Impact factor: 6.053

5.  Pre-mRNA processing is partially impaired in satellite cell nuclei from aged muscles.

Authors:  Manuela Malatesta; Federica Perdoni; Sylviane Muller; Carlo Pellicciari; Carlo Zancanaro
Journal:  J Biomed Biotechnol       Date:  2010-05-19

6.  Adapted physical exercise enhances activation and differentiation potential of satellite cells in the skeletal muscle of old mice.

Authors:  Barbara Cisterna; Marzia Giagnacovo; Manuela Costanzo; Patrizia Fattoretti; Carlo Zancanaro; Carlo Pellicciari; Manuela Malatesta
Journal:  J Anat       Date:  2016-01-06       Impact factor: 2.610

7.  Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide.

Authors:  Fatemeh Talaei; Veroniek M Van Praag; Mahdi H Shishavan; Sjoerd W Landheer; Henk Buikema; Robert H Henning
Journal:  BMC Cell Biol       Date:  2014-01-06       Impact factor: 4.241
  7 in total

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