Literature DB >> 12237554

N-substituted hydroxyureas as urease inhibitors.

Shinichi Uesato1, Yuichiro Hashimoto, Masaru Nishino, Yasuo Nagaoka, Hiroshi Kuwajima.   

Abstract

In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme.

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Year:  2002        PMID： 12237554     DOI： 10.1248/cpb.50.1280

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  5 in total

1.  Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives.

Authors:  Muhammad Hanif; Khurram Shoaib; Muhammad Saleem; Nasim Hasan Rama; Sumera Zaib; Jamshed Iqbal
Journal:  ISRN Pharmacol       Date:  2012-08-13

Review 2.  A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria.

Authors:  Yuri F Rego; Marcelo P Queiroz; Tiago O Brito; Priscila G Carvalho; Vagner T de Queiroz; Ângelo de Fátima; Fernando Macedo
Journal:  J Adv Res       Date:  2018-05-04       Impact factor: 10.479

3.  Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives.

Authors:  Salih Osman Mohammed; Sayed H El El Ashry; Asaad Khalid; Mohamed R Amer; Ahmed M Metwaly; Ibrahim H Eissa; Eslam B Elkaeed; Ahmed Elshobaky; Elsayed E Hafez
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

4.  Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach.

Authors:  Glauber V Da Costa; Moysés F A Neto; Alicia K P Da Silva; Ester M F De Sá; Luanne C F Cancela; Jeanina S Vega; Cássio M Lobato; Juliana P Zuliani; José M Espejo-Román; Joaquín M Campos; Franco H A Leite; Cleydson B R Santos
Journal:  Int J Mol Sci       Date:  2022-07-26       Impact factor: 6.208

5.  Isolation and Characterization of Effective Bacteria That Reduce Ammonia Emission from Livestock Manure.

Authors:  Sun-Il Kim; Wan Heo; So-Jung Lee; Young-Jun Kim
Journal:  Microorganisms       Date:  2021-12-30
  5 in total

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