| Literature DB >> 12237541 |
Yuichi Susuki1, Keiko Hojo, Ikuko Okazaki, Haruhiko Kamata, Masahiko Sasaki, Mitsuko Maeda, Motoyoshi Nomizu, Yoko Yamamoto, Shinsaku Nakagawa, Tadanori Mayumi, Koichi Kawasaki.
Abstract
A bivalent poly(ethylene glycol) or PEG hybrid of fibronectin-related peptides was prepared. An active site peptide (RGD) and its synergistic site peptide (PHSRN) of fibronectin were conjugated with an amino acid-type PEG (aaPEG) to form PHSRN-aaPEG-RGD. A moderate spatial array between RGD and PHSRN in fibronectin may be required for synergic activity. The bivalent hybrid exhibited potent cell spreading activity and exhibited potent anti-metastatic activity in a model of experimental metastasis with B16-BL6 cells in mice. PEG may serve as a spacer for maintaining the desired spatial array.Entities:
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Year: 2002 PMID： 12237541 DOI： 10.1248/cpb.50.1229
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645